BigTTony The weight of the puck isn’t going to tell you much, I only mentioned it in order to explain that flow through the puck begins before drips are visible.
If the coffee is sharp/tart/mouth puckering at your typical ratio, then it is under extracted, if grind adjustments don’t fix it, then the coffee is on the less soluble side & going longer on ratio can help.
If the coffee produced is flat/muddy/lacking in clarity, maybe with an overly powdery mouthfeel, then you may have pushed too much water through the puck, so try going shorter on the ratio to clean things up. If it is both tart/sharp & powdery, then it is likely ground too fine and too short a ratio.
Bitterness alone, without more context/detail doesn’t tell you much.
Roast level can affect the solubility, but Colombians, Rwandans & Kenyans tend to be on the more soluble side, Brazilians, Costa Ricans & Guatemalans on the less soluble side. Always best to actually brew and adjust on your results, rather than 2nd guess what is going to happen.